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KMID : 0043319870100010036
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Archives of Pharmacal Research
1987 Volume.10 No. 1 p.36 ~ p.41
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Effect of Carbon Tetrachloride Intoxication on the Type Conversion of Xanthine Dehydrogenase into Xanthine Oxidase in Rats
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Yoon CG
Huh K
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Abstract
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The conversion of xanthine dehydrogenase(type D) into xanthine oxidase(type O) was significantly increased in serum and liver of all CCl4 treated rats on the necrosis and early cirrhosis stage of liver tissue. In the pretreatment of prednisolone, the ratio of type O per type O+D showed the decreasing tendency in serum, but the significant decrease in liver. In vitro, the conversion of liver xanthine oxidase from type D into type O was markedly increased by following preincubation with lysosomal fraction. The type conversion of xanthine oxidase may be caused by proteolytic enzymes in lysosome.
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